Faculty

Transcriptional mechanisms regulating hematopoietic (myeloid) development and gene expression. Eosinophil effector functions in asthma and other allergic diseases, tissue remodeling and fibrosis. Biochemistry, cell and structural biology of eosinophil protein mediators of inflammation.

Biochemical and NMR studies directed at elucidating the structure and mechanisms of viral proteins.

Molecular genetics of the regulation of the immune system.

Biophysical and biochemical characterization of macromolecular interactions with the emphasis on cancer related proteins.

Mechanisms of cell survival, cell cycle control, metabolism, and genesis of cancer. The PI3K/PTEN/AKT/mTOR signaling. The function of Akt isoforms at the cellular and organismal levels.  

Investigation of the fundamental molecular mechanisms underlying cancer metabolism with a specific focus on nitrogen metabolism.

Extracellular Matrix Signaling in Inflammation, Cancer, and Cardiovascular Development.

Biochemical and NMR studies of protein structure and function, protein-nucleic acid and protein-protein interactions.

Roles of Checkpoint Proteins and Chromatin Modifications in Genome Stability, DNA repair and Telomere Maintenance.

Regulation of Intracellular Trafficking by Molecular Switches and Cascades: The Role of Ypt/Rab GTPases

Structural and functional studies of macromolecular complexes by applying the methods of X-ray crystallography.

Forces and interactions that maintain biologically important conformations in nucleic acids and proteins.

Human nutrition; obesity.

Regulation of the immune response to tumors, immunomodulation by anticancer drugs and gene therapy.

Protein phosphorylation and control mechanisms; membrane protein phosphorylatio.