Faculty

Transcriptional mechanisms regulating hematopoietic (myeloid) development and gene expression. Eosinophil effector functions in asthma and other allergic diseases, tissue remodeling and fibrosis. Biochemistry, cell and structural biology of eosinophil protein mediators of inflammation.

Biochemical and NMR studies directed at elucidating the structure and mechanisms of viral proteins.

The control and organization of protein glycosylation and the role of glycans in protein function. The protein-specific polysialylation of adhesion proteins and signaling molecules.

Role of RB tumor suppressor pathway in development and cancer. Single cell genomics.

Structure and function of plasma proteinase inhibitors. Use of NMR and other spectroscopic methods to determine structure in solution.

Investigation of the fundamental molecular mechanisms underlying cancer metabolism with a specific focus on nitrogen metabolism.

Extracellular Matrix Signaling in Inflammation, Cancer, and Cardiovascular Development.

Biochemical and NMR studies of protein structure and function, protein-nucleic acid and protein-protein interactions.

Roles of Checkpoint Proteins and Chromatin Modifications in Genome Stability, DNA repair and Telomere Maintenance.

Regulation of Intracellular Trafficking by Molecular Switches and Cascades: The Role of Ypt/Rab GTPases

Structural and functional studies of macromolecular complexes by applying the methods of X-ray crystallography.

Structure-function studies, mechanism, biosynthesis, assembly and cellular trafficking of P-type ATPases or Ion pumps. Mechanism and Regulation of Copper transport systems in Human Cells.

Molecular mechanisms of phototransduction; energy coupling mechanisms.

Tumor suppressor proteins (WT1, p53) Mechanisms of regulation of replication and gene expression Induction of apoptosis.

Computer modeling of metabolism.